منابع مشابه
Receptor-regulated ion channels.
Recent advances in the study of receptor-regulated ion channels include the cloning of the genes encoding three types of potassium channel that are favorite targets of receptors for transmitters and hormones. Studies of these channels have also provided a strong indication that G-protein betagamma subunits may gate ion channels via direct protein-protein interactions. Similarities between chann...
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Voltage-gated Ca 2 channels play a key role in controlling Ca 2 entry during cell depolarization. At least 10 genes encode the main ( 1 ) subunits of voltage-gated Ca 2 channels, which have been grouped into two main classes: the high voltage–activated (HVA) and the low voltage–activated (LVA) channels. HVA channels are primarily involved in muscle contraction, synaptic transmission, and hormon...
متن کاملAn intimate relationship: Ca2+ and cardiac ion channels.
We last offered our ideas on the role of reverse EC coupling in the initiation of arrhythmias in 2001.1 At that time we emphasized that spurious Ca release or oscillations in Ca levels could serve as possible triggers for arrhythmias. Since then much has been done to confirm this role for intracellular Ca . At that time we did not discuss the role of Ca cycling in the maintenance or conversion ...
متن کاملSelenoprotein W redox-regulated Ca2+ channels correlate with selenium deficiency-induced muscles Ca2+ leak
Selenium (Se) deficiency induces Ca2+ leak and calcification in mammal skeletal muscles; however, the exact mechanism is still unclear. In the present study, both Se-deficient chicken muscle models and selenoprotein W (SelW) gene knockdown myoblast and embryo models were used to study the mechanism. The results showed that Se deficiency-induced typical muscular injuries accompanied with Ca2+ le...
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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2011
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2011.44.10.635